Trot, a young girl from California, and peg-legged Cap'n Bill, stranded in an underwater cave, undertake a journey through the Land of Mo to Oz when befriended by a strange creature--the Ork.

Dr. John Dolittle lives in solitude behind the high walls of his lush manor in 19th-century England. His only companionship comes from an array of exotic animals that he speaks to on a daily basis. But when young Queen Victoria becomes gravely ill, the eccentric doctor and his furry friends embark on an epic adventure to a mythical island to find the cure.